Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

@article{Franklin2003StructureAF,
  title={Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).},
  author={Matthew C. Franklin and Saloumeh Kadkhodayan and Heidi Ackerly and Daniela Alexandru and Mark D Distefano and Linda O. Elliott and John A. Flygare and Grace Mausisa and David C Okawa and Danny Chee Tiong Ong and Domagoj Vucic and Kurt D Deshayes and Wayne J. Fairbrother},
  journal={Biochemistry},
  year={2003},
  volume={42 27},
  pages={8223-31}
}
Melanoma inhibitor of apoptosis (ML-IAP) is a potent anti-apoptotic protein that is upregulated in a number of melanoma cell lines but not expressed in most normal adult tissues. Overexpression of IAP proteins, such as ML-IAP or the ubiquitously expressed X-chromosome-linked IAP (XIAP), in human cancers has been shown to suppress apoptosis induced by a variety of stimuli. Peptides based on the processed N-terminus of Smac/DIABLO can negate the ability of overexpressed ML-IAP or XIAP to suppress… CONTINUE READING

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