Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.

@article{Morohoshi2000StructureAE,
  title={Structure and expression pattern of a human MTG8/ETO family gene, MTGR1.},
  author={Fumiko Morohoshi and Shohei Mitani and Naoto Mitsuhashi and Issay Kitabayashi and Ei-ichi Takahashi and Miwako Suzuki and Nobuo Munakata and M. Ohki},
  journal={Gene},
  year={2000},
  volume={241 2},
  pages={287-95}
}
AML1-MTG8 fusion protein, which is produced from the rearranged gene formed between AML1 and MTG8 in myeloid leukemia with t(8;21) chromosomal translocation, plays an important role in the pathogenesis of leukemia. We previously showed that ectopically expressed AML1-MTG8 fusion protein is associated with an MTG8-like protein in the mouse myeloid precursor cell line L-G, and this association seemed to be required for AML1-MTG8 to stimulate proliferation. As a candidate cDNA for this MTG8-like… CONTINUE READING