Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor

  title={Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor},
  author={I. Gozes and M. Bodner and Y. Shani and M. Fridkin},
  • I. Gozes, M. Bodner, +1 author M. Fridkin
  • Published 1986
  • Biology, Medicine
  • Peptides
  • To identify the VIP biosynthetic pathways, we have isolated the human VIP gene, using synthetic oligodeoxynucleotides. These specific hybridization probes were constructed according to the neuroblastoma VIP-cDNA sequence and contained up to 39 bases. The gene structure was deduced by direct chemical nucleotide sequencing. Six exons were thus far discovered; among them two short exons, one encoding VIP and the second encoding PHM-27 (a peptide having a N-terminal histidine and C-terminal… CONTINUE READING
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