Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.

@article{Stride1996StructureAE,
  title={Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.},
  author={Brenda D. Stride and Gunnar Valdimarsson and James H. Gerlach and Gary M. Wilson and Susan P. C. Cole and R. G. Deeley},
  journal={Molecular pharmacology},
  year={1996},
  volume={49 6},
  pages={962-71}
}
In vitro, overexpression of the human multidrug-resistance protein (MRP) causes a form of multidrug resistance similar to that conferred by P-glycoprotein, although the two proteins are only very distantly related. Studies with MRP-enriched membrane vesicles have demonstrated that the protein can bind and transport cysteinyl leukotrienes, as well as some other glutathione conjugates, with high affinity. In contrast, there is no direct evidence of the ability of MRP to bind or transport… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…