Structure and expression of the gene encoding a Broad-Complex homolog in the silkworm, Bombyx mori.

@article{Nishita2004StructureAE,
  title={Structure and expression of the gene encoding a Broad-Complex homolog in the silkworm, Bombyx mori.},
  author={Yoshinori Nishita and Shigeharu Takiya},
  journal={Gene},
  year={2004},
  volume={339},
  pages={
          161-72
        }
}
The steroid hormone ecdysone (20-hydroxyexdysone) initiates metamorphosis and also larval ecdysis in many insects by activating a cascade of genes that includes primary response genes (early genes), most of which encode transcriptional regulators, and secondary response genes (late genes) regulated by the early genes. One of the early genes, Broad-Complex (BR-C), a key regulator of the ecdysone cascade, shares a common amino-terminal BTB domain which is fused by alternative splicing to one of… CONTINUE READING

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