Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

  title={Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica},
  author={Maja Adamska and Claire Larroux and Marcin Adamski and Kathryn M. Green and Erica M. Lovas and Demian Koop and Gemma Sian Richards and Christin Zwafink and Bernard M. Degnan},
  journal={Evolution \& Development},
SUMMARY Wnt‐signalling plays a critical role in animal development, and its misregulation results in serious human diseases, including cancer. While the Wnt pathway is well studied in eumetazoan models, little is known about the evolutionary origin of its components and their functions. Here, we have identified key machinery of the Wnt–β‐catenin (canonical)‐signalling pathway that is encoded in the Amphimedon queenslandica (Demospongiae; Porifera) genome, namely Wnt, Fzd, SFRP, Lrp5/6, Dvl… 

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