Structure and expression of a human oxytocin receptor

@article{Kimura1992StructureAE,
  title={Structure and expression of a human oxytocin receptor},
  author={T. Kimura and O. Tanizawa and K. Mori and M. Brownstein and H. Okayama},
  journal={Nature},
  year={1992},
  volume={356},
  pages={526-529}
}
  • T. Kimura, O. Tanizawa, +2 authors H. Okayama
  • Published 1992
  • Biology, Medicine
  • Nature
  • JUST before the onset of labour, uterine myometrium becomes extremely sensitive to oxytocin1 for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors2,3. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acidpolypeptide with7transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in Xenopus… CONTINUE READING
    416 Citations

    Topics from this paper.

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Uterine contraction has a negative impact on implantation and pregnancy rates. Inhibition of oxytocin receptors decreases uterine contraction frequency both on pregnant and non-pregnant… Expand
    ConditionsInfertility, Female
    InterventionDrug
    Oxytocin and oxytocin receptor gene expression in the uterus.
    • 81
    The Structure and Regulation of the Oxytocin Receptor
    • 45
    Characterization and expression of oxytocin and the oxytocin receptor.
    • 31
    The ovine endometrial oxytocin receptor.
    Oxytocin Receptor Regulation and Action in a Human Granulosa-Lutein Cell Line1
    • 16
    • PDF
    The regulation of oxytocin receptor expression in human myometrial monolayer culture.
    • S. Adachi, M. Oku
    • Chemistry, Medicine
    • Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
    • 1995
    • 52

    References

    SHOWING 1-10 OF 24 REFERENCES
    Oxytocin receptors in the human uterus during pregnancy and parturition.
    • 466
    Oxytocin receptors in the ovine corpus luteum.
    • 37
    Cloning and expression of cDNA for a human thromboxane A2 receptor
    • 632
    Oxytocin and vasopressin binding sites in human and bovine ovaries.
    • 43
    Molecular characterization of a functional cDNA for rat substance P receptor.
    • 425