Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein

  title={Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein},
  author={B. Dworniczak and M. E. Mirault},
  journal={Nucleic acids research},
  volume={15 13},
In all eukaryotes examined so far, hsp70 gene families include cognate genes (hsc70) encoding proteins of about 70 Kd which are expressed constitutively during normal growth and development. We have investigated the structural relationship of heat-inducible and cognate members of the human hsp70 gene family. Among several human genomic clones isolated using Drosophila hsp/hsc70 probes, one contained an hsc70 gene. Its complete sequence is reported here. It is split by eight introns and encodes… CONTINUE READING


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