Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.

@article{Kornfeld1989StructureAE,
  title={Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.},
  author={Kerry Kornfeld and Robert B. Saint and Philip A Beachy and Peter J. Harte and Debra A. Peattie and David S. Hogness},
  journal={Genes & development},
  year={1989},
  volume={3 2},
  pages={243-58}
}
The 77-kb primary transcript of the homeotic Ultrabithorax (Ubx) gene is alternatively spliced to yield at least five different coding regions. Each is restricted to either a 3.2- or a 4.3-kb size class generated by alternative polyadenylation. The pathways for splicing and polyadenylation are therefore coordinately regulated, and because the relative abundance of the respective mRNAs varies throughout development, these pathways also appear to be developmentally regulated. Translation of these… CONTINUE READING

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