Structure and evolutionary history of a large family of NLR proteins in the zebrafish.

  title={Structure and evolutionary history of a large family of NLR proteins in the zebrafish.},
  author={Kerstin Howe and Philipp H. Schiffer and Julia Zielinski and Thomas Wiehe and Gavin K Laird and John C. Marioni and Onuralp Soylemez and Fyodor A. Kondrashov and Maria Leptin},
  journal={Open biology},
  volume={6 4},
Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins. Mammals have small numbers of NLR proteins, whereas in some species, mostly those without adaptive immune systems, NLRs have expanded into very large families. We describe a family of nearly 400 NLR proteins encoded in the zebrafish genome. The proteins share a defining overall structure, which… CONTINUE READING
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