Structure and dynamics of the force-generating domain of myosin probed by multifrequency electron paramagnetic resonance.

Abstract

Spin-labeling and multifrequency EPR spectroscopy were used to probe the dynamic local structure of skeletal myosin in the region of force generation. Subfragment 1 (S1) of rabbit skeletal myosin was labeled with an iodoacetamide spin label at C707 (SH1). X- and W-band EPR spectra were recorded for the apo state and in the presence of ADP and nucleotide… (More)
DOI: 10.1529/biophysj.107.124305

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