Structure and dynamics of protein interactions

Abstract

56 Small molecules can non-specifically modulate the environment of a protein by binding strongly to it, specifically interfering with its activity, or by interacting weakly, but specifically, as molecular spies reporting on the interactions of the protein with other macromolecules. Our group focuses on three main fields of direct biomedical interest: i) nucleoid-associated proteins of potentially pathogenic bacteria. These proteins modulate gene expression in response to environmental changes and are essential for infection; ii) the regulation of low molecular weight phosphatases and Src kinase, two key proteins in tyrosine phosphorylation signalling; and iii) drug design and the characterisation of the space of potential low molecular weight protein ligands.

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Cite this paper

@inproceedings{Pons2008StructureAD, title={Structure and dynamics of protein interactions}, author={Miquel Pons and Jes{\'u}s Garc{\'i}a and Juan Carlos Paniagua and Fortian and Oriol Marim{\'o}n and Lidia Ballester}, year={2008} }