Structure and dynamics of micelle-associated human immunodeficiency virus gp41 fusion domain.

@article{Jaroniec2005StructureAD,
  title={Structure and dynamics of micelle-associated human immunodeficiency virus gp41 fusion domain.},
  author={Christopher P Jaroniec and Joshua D. Kaufman and Stephen J. Stahl and Mathias Viard and Robert Blumenthal and Paul T Wingfield and Adriaan Bax},
  journal={Biochemistry},
  year={2005},
  volume={44 49},
  pages={16167-80}
}
The N-terminal fusion domain of the HIV-1 gp41 envelope glycoprotein is responsible for initiating the fusion of viral and cellular membranes, leading to the subsequent infection of the host cell by HIV-1. We have investigated the backbone structure and dynamics of the 30 N-terminal residues of HIV-1 gp41 in membrane-mimicking environments using NMR spectroscopy and (15)N- and (15)N,(13)C,(2)H-labeled peptides. Similar (15)N-(1)H HSQC spectra were obtained in a variety of detergents, including… CONTINUE READING

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