Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments.

@article{Chiodi2000StructureAD,
  title={Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments.},
  author={Ilaria Chiodi and Marco Biggiogera and Marco Denegri and Margherita Corioni and Florian Weighardt and Fabio Cobianchi and Silvano Riva and Giuseppe Biamonti},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 22)},
  pages={4043-53}
}
We have previously described HAP, a novel hnRNP protein that is identical both to SAF-B, a component of the nuclear scaffold, and to HET, a transcriptional regulator of the gene for heat shock protein 27. After heat shock, HAP is recruited to a few nuclear bodies. Here we report the characterisation of these bodies, which are distinct from other nuclear components such as coiled bodies and speckles. The formation of HAP bodies is part of a general cell response to stress agents, such as heat… CONTINUE READING
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