Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

  title={Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.},
  author={Sara Ghazi-Tabatabai and Suraj Saksena and Judith M. Short and Ajaybabu V. Pobbati and Dmitry B. Veprintsev and R. A. Crowther and Scott D Emr and Edward H. Egelman and Roger L Williams},
  volume={16 9},
The ESCRT machinery mediates sorting of ubiquitinated transmembrane proteins to lysosomes via multivesicular bodies (MVBs) and also has roles in cytokinesis and viral budding. The ESCRT-III subunits are metastable monomers that transiently assemble on membranes. However, the nature of these assemblies is unknown. Among the core yeast ESCRT-III subunits, Snf7 and Vps24 spontaneously form ordered polymers in vitro. Single-particle EM reconstruction of helical Vps24 filaments shows both parallel… CONTINUE READING
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