Structure and dimerization of a soluble form of B7-1.

  title={Structure and dimerization of a soluble form of B7-1.},
  author={Shinji Ikemizu and Robert J C Gilbert and Janet A. Fennelly and Alison V Collins and Karl Harlos and Edith Yvonne Jones and David I Stuart and Simon J Davis},
  volume={12 1},
B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 A resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal… CONTINUE READING