Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.

@article{Dymecki1992StructureAD,
  title={Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.},
  author={Susan M Dymecki and Patty Zwollo and Karin Zeller and Francis P. Kuhajda and Stephen V. Desiderio},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 7},
  pages={4815-23}
}
The murine blk gene, which encodes a B-lymphoid-specific tyrosine kinase of the Src family (p55blk), contains 13 exons that span more than 30 kilobases of DNA on chromosome 14. In the first three exons, which encode the 5'-untranslated region and N-terminal amino acid sequence unique to p55blk, the blk gene differs from other members of the src family; in the last 10 exons, the organization of the blk gene is similar to that of other src genes. By primer extension and S1 nuclease protection… CONTINUE READING