Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.

  title={Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.},
  author={D. Travis Gallagher and Gary L Gilliland and Gaoyi Xiao and James Zondlo and Kathryn E Fisher and Diana Chinchilla and Edward Eisenstein},
  volume={6 4},
BACKGROUND Feedback inhibition of biosynthetic threonine deaminase (TD) from Escherichia coli provided one of the earliest examples of protein-based metabolic regulation. Isoleucine, the pathway end-product, and valine, the product of a parallel pathway, serve as allosteric inhibitor and activator, respectively. This enzyme is thus a useful model system for studying the structural basis of allosteric control mechanisms. RESULTS We report the crystal structure of TD at 2.8 A resolution. The… CONTINUE READING
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