Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis

@article{Mullins2001StructureAC,
  title={Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis},
  author={Robert F. Mullins and Natalia Aptsiauri and Gregory S. Hageman},
  journal={Eye},
  year={2001},
  volume={15},
  pages={390-395}
}
Purpose The ocular fundi of many patients with membranoproliferative glomerulonephritis type II (MPGN-II) are characterised by the presence of deposits within Bruch's membrane that resemble drusen, hallmark lesions associated with age-related macular degeneration (AMD). Glomerulonephritis (GN)-associated drusen appear at a younger age, however, than do drusen in individuals with AMD. In light of recent evidence that immune-mediated events participate in drusen biogenesis and AMD, we examined… CONTINUE READING
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