Structure and chromosomal localization of the mouse oncomodulin gene

  title={Structure and chromosomal localization of the mouse oncomodulin gene},
  author={Frank Staubli and A. U. Klein and J{\"u}rg Rentsch and H. Hameister and Martin W. Berchtold},
  journal={Mammalian Genome},
The rat gene encoding oncomodulin (OM), a small calcium-binding protein, is under the control of a solo LTR derived from an endogenous intracisternal A-particle. The latter sequence is the only OM promoter analyzed so far. In order to study cell-type-specific OM expression in a species lacking LTR sequences in the OM locus, we initially synthesized an OM cDNA from mouse placenta. By sequencing, we found a 137-bp-long 5′ leader region that differed markedly from its rat counterpart but had high… 
Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice
Deletion of oncomodulin, which is predominately found in outer hair cells, leads to a progressive hearing loss after 1 month, suggesting that Ocm critically protects hearing in the mature ear.


The intracisternal A particle derived solo LTR promoter of the rat oncomodulin gene is not present in the mouse gene
It is shown here that the oncomodulin LTR is a member of a small subset of sequence related solo LTR elements present in the rat genome and that a full length IAP genome containing LTRs of this type is no longer present.
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