Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases.

@article{Marmorstein2004StructureAC,
  title={Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases.},
  author={Ronen Marmorstein},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt 6},
  pages={904-9}
}
The yeast Sir2 (silent information regulator-2) protein functions as an NAD(+)-dependent histone deacetylase to silence gene expression from the mating-type locus, tolomeres and rDNA and also promotes longevity and genome stability in response to calorie restriction. Homologues of yeast Sir2 have been identified in the three domains of bacteria, archaea and eukaryotes; in mammalian cells, Sir2 proteins also deacetylate non-histone proteins such as the p53 tumour suppressor protein, alpha… CONTINUE READING

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