Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.

@article{Hosokawa2008StructureAC,
  title={Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.},
  author={Masakiyo Hosokawa},
  journal={Molecules},
  year={2008},
  volume={13 2},
  pages={412-31}
}
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can be classified into five major groups denominated CES1-CES5, according to the homology of the amino acid sequence, and the majority of CESs that have been identified belong to the CES1 or CES2 family. The substrate… CONTINUE READING
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