Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.

@article{Edwards2004StructureAB,
  title={Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.},
  author={Daniel J Edwards and Brian L M{\'a}rquez and Lisa M Nogle and Kerry McPhail and Douglas E Goeger and Mary Ann Roberts and William H Gerwick},
  journal={Chemistry & biology},
  year={2004},
  volume={11 6},
  pages={817-33}
}
A screening program for bioactive compounds from marine cyanobacteria led to the isolation of jamaicamides A-C. Jamaicamide A is a novel and highly functionalized lipopeptide containing an alkynyl bromide, vinyl chloride, beta-methoxy eneone system, and pyrrolinone ring. The jamaicamides show sodium channelblocking activity and fish toxicity. Precursor feeding to jamaicamide-producing cultures mapped out the series of acetate and amino acid residues and helped develop an effective cloning… CONTINUE READING
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