Structure and biosynthesis of a new antifungal antibiotic, phthoramycin.

@article{Nakagawa1989StructureAB,
  title={Structure and biosynthesis of a new antifungal antibiotic, phthoramycin.},
  author={A. Nakagawa and S. Miura and H. Imai and N. Imamura and S. O̅mura},
  journal={The Journal of antibiotics},
  year={1989},
  volume={42 8},
  pages={
          1324-7
        }
}
  • A. Nakagawa, S. Miura, +2 authors S. O̅mura
  • Published 1989
  • Chemistry, Medicine
  • The Journal of antibiotics
  • Sir: Wehave demonstrated that the feeding experiments using 13C enriched precursors are useful means for structure elucidation of polyketide antibiotics.1*^ In the course of screening for antifungal substances, a new macrolide antibiotic, phthoramycin (1: MP 116~119°C, C40H68O12) was found in the cultured broth of Streptomyces sp. WK-1875.3) We now report structural elucidation and biosynthesis4'53 of 1 by means of feeding experiments using relabeled precursors and 400 MHz*H NMRspectroscopy… CONTINUE READING
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