Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

@inproceedings{Schramma2015StructureAB,
  title={Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink},
  author={Kelsey R. Schramma and Leah B. Bushin and Mohammad R Seyedsayamdost},
  booktitle={Nature chemistry},
  year={2015}
}
Streptococcal bacteria use peptide signals as a means of intraspecies communication. These peptides can contain unusual post-translational modifications, providing opportunities for expanding our understanding of nature's chemical and biosynthetic repertoires. Here, we have combined tools from natural products discovery and mechanistic enzymology to elucidate the structure and biosynthesis of streptide, a streptococcal macrocyclic peptide. We show that streptide bears an unprecedented post… CONTINUE READING
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