Structure and biology of tissue factor pathway inhibitor.

  title={Structure and biology of tissue factor pathway inhibitor.},
  author={Madhu S. Bajaj and Jens J. Birktoft and Sarah A. Steer and Satya P. Bajaj},
  journal={Thrombosis and haemostasis},
  volume={86 4},
Human tissue factor pathway inhibitor (TFPI) is a modular protein comprised of three Kunitz type domains flanked by peptide segments that are less structured. The sequential order of the elements are: an N-terminal acidic region followed by the first Kunitz domain (K1), a linker region, a second Kunitz domain (K2), a second linker region, the third Kunitz domain (K3), and the C-terminal basic region. The K1 domain inhibits factor VIIa complexed to tissue factor (TF) while the K2 domain inhibits… CONTINUE READING

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