Structure and biological activity of botulinum neurotoxin.

  title={Structure and biological activity of botulinum neurotoxin.},
  author={Bibhuti R Dasgupta},
  journal={Journal de physiologie},
  volume={84 3},
Botulinum neurotoxin appears to undergo structural alterations after synthesis and also before it inhibits neurotransmitter release. Discussions and conjectures are presented in this context: 1. At what sites on the 150 kDa neurotoxin does posttranslational proteolytic processing occur? 2. Does neurotransmitter inhibition depend on separation of a segment of the neurotoxin from the rest of the molecule? 3. At what step in the intoxication pathway does activation of neurotoxin (enhanced… CONTINUE READING

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