Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.

@article{Sugiyama2014StructureAB,
  title={Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.},
  author={Ryosuke Sugiyama and S. Nishimura and N. Matsumori and Y. Tsunematsu and A. Hattori and H. Kakeya},
  journal={Journal of the American Chemical Society},
  year={2014},
  volume={136 14},
  pages={
          5209-12
        }
}
Polyene macrolactams are a class of microbial metabolites, many of which show potent biological activities with unidentified modes of action. Here we report that 8-deoxyheronamide C, a new 20-membered polyene macrolactam from a marine-derived actinomycete Streptomyces sp., is a unique membrane binder. 8-Deoxyheronamide C showed a characteristic sensitivity profile against fission yeast sterol mutant cells, indicating that the metabolite targets cell membranes. We detected tight physical… Expand
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