Structure and assembly of P-pili: a protruding hinge region used for assembly of a bacterial adhesion filament.

@article{Mu2006StructureAA,
  title={Structure and assembly of P-pili: a protruding hinge region used for assembly of a bacterial adhesion filament.},
  author={X Mu and Esther Bullitt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 26},
  pages={9861-6}
}
High-resolution structures of macromolecular complexes offer unparalleled insight into the workings of biological systems and hence the interplay of these systems in health and disease. We have adopted a multifaceted approach to understanding the pathogenically important structure of P-pili, the class I adhesion pili from pyelonephritic Escherichia coli. Our approach combines electron cryomicroscopy, site-directed mutagenesis, homology modeling, and energy calculations, resulting in a high… CONTINUE READING
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