Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

@article{Verstraete2017StructureAA,
  title={Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma},
  author={Kenneth Verstraete and Frank Peelman and Harald Braun and Juan Lopez and Dries Van Rompaey and Ann Dansercoer and Isabel Vandenberghe and Kristof Pauwels and Jan Tavernier and Bart N. Lambrecht and Hamida Hammad and Hans De Winter and Rudi Beyaert and Guy Lippens and Savvas N. Savvides},
  journal={Nature Communications},
  year={2017},
  volume={8}
}
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maximally harnessing its therapeutic potential via structural and mechanistic considerations. Here we employ an integrative experimental approach focusing on productive and antagonized TSLP complexes and… 

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