Structure and adsorption properties of commercial calcium phosphate adjuvant.

  title={Structure and adsorption properties of commercial calcium phosphate adjuvant.},
  author={Dongping Jiang and Gnanasiri S. Premachandra and Cliff T. Johnston and Stanley L. Hem},
  volume={23 5},
Calcium phosphate adjuvant is a commercially available vaccine adjuvant that potentiates the immune response to antigens. Although its name suggests that it is Ca3(PO4)2, X-ray diffraction, FTIR spectroscopy, thermal analysis and the Ca/P molar ratio identify commercial calcium phosphate adjuvant as non-stoichiometric hydroxyapatite, Ca10-x (HPO4)x (PO4)6-x (OH)2-x, where x varies from 0 to 2. The surface charge is pH-dependent (point of zero charge = 5.5). Consequently, commercial calcium… CONTINUE READING
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