Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp

  title={Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp},
  author={Zhenjian Lin and Michael Koch and Christopher D Pond and Gaiselle F Mabeza and Romell A. Seronay and Gisela P. Concepcion and Louis R Barrows and Baldomero M. Olivera and Eric W. Schmidt},
  journal={The Journal of Antibiotics},
A novel lumun-lumun sampling methodology was used to obtain a large diversity of micromollusks, including the new species Lienardia totopotens. In turn, from L. totopotens we cultivated a Streptomyces sp. strain that contained new and known spirotetronate polyketides, lobophorins (1–5). The structures were elucidated using spectroscopy, and the compounds were evaluated for cytotoxicity to human cells and activity against Mycobacterium tuberculosis, Bacillus subtilis, Pseudomonas aeruginosa and… 

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