Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels.

@article{Daly2011StructureAA,
  title={Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels.},
  author={Norelle L Daly and Brid P. Callaghan and Richard J Clark and Simon T. Nevin and David J Adams and David J. Craik},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 12},
  pages={10233-7}
}
α-Conotoxins are peptides from cone snails that target the nicotinic acetylcholine receptor (nAChR). RgIA and Vc1.1 have analgesic activity in animal pain models. Both peptides target the α9α10 nAChR and inhibit N-type calcium channels via GABA(B) receptor activation, but the mechanism of action of analgesic activity is unknown. PeIA has previously been… CONTINUE READING