Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.

@article{Mrquez2002StructureAA,
  title={Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.},
  author={Brian L M{\'a}rquez and Karl Shawn Watts and Alexandre F. T. Yokochi and Mary Ann Roberts and Pascal Verdier-Pinard and Jorge I. Jim{\'e}nez and Ernest Hamel and Paul J. Scheuer and William H Gerwick},
  journal={Journal of natural products},
  year={2002},
  volume={65 6},
  pages={866-71}
}
Hectochlorin (1) was isolated from marine isolates of Lyngbya majuscula collected from Hector Bay, Jamaica, and Boca del Drago Beach, Bocas del Toro, Panama. The planar structure was deduced by one- and two-dimensional NMR spectroscopy. X-ray crystallography was used to determine the absolute stereochemistry of hectochlorin as 2S,3S,14S,22S. Hectochlorin is equipotent to jasplakinolide (5) in its ability to promote actin polymerization, but unlike jasplakinolide, is unable to displace a… CONTINUE READING

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