Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex

@article{Tosi2013StructureAS,
  title={Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex},
  author={Alessandro Tosi and Caroline Marie Burrell Haas and Franz Herzog and Andrea Gilmozzi and Otto Berninghausen and Charlotte Ungewickell and Christian B. Gerhold and Kristina Lakomek and Ruedi Aebersold and Roland Beckmann and Karl-Peter Hopfner},
  journal={Cell},
  year={2013},
  volume={154},
  pages={1207-1219}
}
INO80/SWR1 family chromatin remodelers are complexes composed of >15 subunits and molecular masses exceeding 1 MDa. Their important role in transcription and genome maintenance is exchanging the histone variants H2A and H2A.Z. We report the architecture of S. cerevisiae INO80 using an integrative approach of electron microscopy, crosslinking and mass spectrometry. INO80 has an embryo-shaped head-neck-body-foot architecture and shows dynamic open and closed conformations. We can assign an Rvb1… CONTINUE READING
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