Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes

@inproceedings{Kobe2002StructureAR,
  title={Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes},
  author={Bostjan Kobe and Ian G. Jennings and Richard G. H. Cotton},
  year={2002}
}
Phenylalanine hydroxylase (PAH) is a metabolic enzyme that converts Phe to Tyr using molecular oxygen, enzyme-bound iron, and a 6R-tetrahydrobiopterin (BH4) cofactor (1, 2, 3). PAH is a member of the aromatic amino acid hydroxylase family, together with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH). TH and TPH are involved in the biosynthesis of the neurotransmitters, L-DOPA and serotonin, respectively. The aromatic amino acid hydroxylases share a similar enzyme mechanism and have… CONTINUE READING