Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

@inproceedings{Wibmer2017StructureAR,
  title={Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape},
  author={Constantinos Kurt Wibmer and Jason Gorman and Gabriel Ozorowski and Jinal N Bhiman and Daniel J Sheward and Debra Holton Elliott and Julie A Rouelle and Ashley A Smira and M. Gordon Joyce and Nonkululeko Ndabambi and Aliaksandr Druz and Mangai Asokan and Dennis R. Burton and Mark Connors and Salim S Abdool Karim and John R. Mascola and James E Robinson and Andrew B. Ward and Carolyn Williamson and Peter D. Kwong and Lynn Morris and Penny L Moore},
  booktitle={PLoS pathogens},
  year={2017}
}
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post… CONTINUE READING