Structure and Nomenclature of Steroids

  title={Structure and Nomenclature of Steroids},
  author={A. Kasal},
A formula of a steroid compound is easily recognized by its four-membered hydrocarbon core (Fig. 1.1a). My little grand daughter called it “a little cottage”, more advanced beginners may recall the term “cyclopentenoperhydrophenanthrene”. All the thousands of natural and synthetic steroids are derivatives of that core. Ring A is the cyclohexane ring on the left; it is attached to another six-membered ring B. The C ring follows, the D ring is a cyclopentane system. 
Steroidal sapogenins from genus Trillium: Chemistry, synthesis, and opportunities in neuro-active steroids designing
Abstract The genus Trillium belongs to the family Melanthiaceae (alt. Trilliaceae) and comprises around 50 accepted species. Steroidal saponins are the principal phytomolecules in Trillium. A totalExpand
Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery.
118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities, and herbarin, periconianone A, and periconIANone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition. Expand
Aptatope mapping of the binding site of a progesterone aptamer on the steroid ring structure.
The mapping of the binding site of the only progesterone aptamer published to date is reported, in an approach referred to as aptatope mapping, and the moieties involved in aptamer-progesterone binding are elucidated. Expand
Effect of cooking on physicochemical properties and volatile compounds in lotus root (Nelumbo nucifera Gaertn).
Instrumental texture measurements indicate that the characteristic post-cooked retention of crunchiness in lotus root is likely to be related to retention of its springiness index through the cooking process. Expand
Partial Least Square Model (PLS) as a Tool to Predict the Diffusion of Steroids Across Artificial Membranes
The present study attempts to decode the permeability by correlating the apparent permeability coefficient (Papp) of 33 steroids with their properties (physicochemical and structural) and specific properties were proved to be more important than others in terms of drugs Papp. Expand
Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products.
........................................................................................................................................ xii CHAPTER 1. Polyenes: An Overview of the Biology andExpand
Metabolic effects of 5α-reductase inhibition in humans
This thesis is concerned with Androgens in health and disease, specifically the role of testosterone in the latter stages of women’s sexual development. Expand
Investigating the mechanisms mediating the outcomes of prenatal stress


D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase.
The new D-ring modified estrone derivatives bearing a propyl and a 1-pyridin-3-ylmethyl moiety had IC(50) values of 1 nM when tested in placental microsomes for the inhibition of STS, up to 18-fold more potent than EMATE, the very first highly potent irreversible steroidal STS inhibitor. Expand
The Chemistry of the Steroids
In view of the comprehensive article on the sterols by Heilbron & Jones (1), of the treatment by Kendall (2) and by Kamm & Pfiffner elsewhere in this Volume of the various groups of steroid hormones,Expand
Synthesis of 1,10-seco-5α-estr-1 -ynes: potential mechanism-based inhibitors of 3α- and 3β-hydroxysteroid dehydrogenases
Oxido-reductase reactions mediated by 3α- and 3β-hydroxysteroid dehydrogenases alter the biological effects of steroid hormones. A novel and practical synthetic route from 19-nortestosterone 1 toExpand
Androgen receptor binding and antiandrogenic activity of some 4,5-secoandrostanes and ring B cyclopropanoandrostanes.
The opening of ring A of androgens, such as testosterone or 17 alpha-methyltestosterone, moderately reduced the binding and changed the biological activity to weakly antiandrogenic. Expand
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
The first synthesis of enantiomeric lithocholic acid and chenodeoxycholic acid through ent-CDCA and ent-2 via ent-testosterone is reported, highlighting the potential for using enantioselectivity as a way to distinguish between receptor and nonreceptor-mediated functions of natural bile acids. Expand
Estrogen-Like Compounds for Ischemic Neuroprotection
A library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens, which are potent in protecting brain tissue from cerebral ischemia/reperfusion injury and prime candidates for use in stroke neuroprotection. Expand
Enantiomers of Neuroactive Steroids Support a Specific Interaction with the GABA-C Receptor as the Mechanism of Steroid Action
The results strongly suggest that the actions of these neuroactive steroids are mediated by interactions with chiral regions of the target protein, rather than by a change in membrane properties (including lateral pressure). Expand
It has now been shown that patients with Addison's disease and adrenalectomized animals can be protected by an extract of the adrenal cortex against the fatal consequences which are associated with a deficiency of this essential gland. Expand
Recent developments in structure–activity relationships for steroid modulators of GABAA receptors
Non-naturally occurring enantiomers of both positive and negative modulators have been studied to provide further evidence for the existence of specific steroid binding sites on the receptors and to delineate the structural features required for compounds to modulate receptor function via steroids binding sites. Expand