Structure and Nomenclature of Steroids

  title={Structure and Nomenclature of Steroids},
  author={Alexander Kasal},
A formula of a steroid compound is easily recognized by its four-membered hydrocarbon core (Fig. 1.1a). My little grand daughter called it “a little cottage”, more advanced beginners may recall the term “cyclopentenoperhydrophenanthrene”. All the thousands of natural and synthetic steroids are derivatives of that core. Ring A is the cyclohexane ring on the left; it is attached to another six-membered ring B. The C ring follows, the D ring is a cyclopentane system. 
Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery.
118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities, and herbarin, periconianone A, and periconIANone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.
Partial Least Square Model (PLS) as a Tool to Predict the Diffusion of Steroids Across Artificial Membranes
The present study attempts to decode the permeability by correlating the apparent permeability coefficient (Papp) of 33 steroids with their properties (physicochemical and structural) and specific properties were proved to be more important than others in terms of drugs Papp.
Development of Tandem Chemical Processes for the Synthesis of Bioactive Natural Products.
An overview of the Biology and Chemistry of Polyenes and their applications in medicine and science is presented.
Metabolic effects of 5α-reductase inhibition in humans
This thesis is concerned with Androgens in health and disease, specifically the role of testosterone in the latter stages of women’s sexual development.
Investigating the mechanisms mediating the outcomes of prenatal stress


The Chemistry of the Steroids
In view of the comprehensive article on the sterols by Heilbron & Jones (1), of the treatment by Kendall (2) and by Kamm & Pfiffner elsewhere in this Volume of the various groups of steroid hormones,
Synthesis of 1,10-seco-5α-estr-1 -ynes: potential mechanism-based inhibitors of 3α- and 3β-hydroxysteroid dehydrogenases
A novel and practical synthetic route from 19-nortestosterone 1 to (3R,S)-1, 10-seco-5α-estr-1-yne-3,17β-diol 13a and structurally related analogues has been developed so that the potential of these 1,10-secosteroids as mechanism-based inhibitors of 3α- and 3β-hydroxysteroid dehydrogenases can be evaluated.
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
The first synthesis of enantiomeric lithocholic acid and chenodeoxycholic acid through ent-CDCA and ent-2 via ent-testosterone is reported, highlighting the potential for using enantioselectivity as a way to distinguish between receptor and nonreceptor-mediated functions of natural bile acids.
Estrogen-Like Compounds for Ischemic Neuroprotection
A library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens, which are potent in protecting brain tissue from cerebral ischemia/reperfusion injury and prime candidates for use in stroke neuroprotection.
Enantiomers of Neuroactive Steroids Support a Specific Interaction with the GABA-C Receptor as the Mechanism of Steroid Action
The results strongly suggest that the actions of these neuroactive steroids are mediated by interactions with chiral regions of the target protein, rather than by a change in membrane properties (including lateral pressure).
It has now been shown that patients with Addison's disease and adrenalectomized animals can be protected by an extract of the adrenal cortex against the fatal consequences which are associated with a deficiency of this essential gland.