Structure and Mechanism of Yeast RNA Triphosphatase An Essential Component of the mRNA Capping Apparatus

@article{Lima1999StructureAM,
  title={Structure and Mechanism of Yeast RNA Triphosphatase An Essential Component of the mRNA Capping Apparatus},
  author={Christopher D Lima and Li Kai Wang and Stewart Shuman},
  journal={Cell},
  year={1999},
  volume={99},
  pages={533-543}
}
RNA triphosphatase is an essential mRNA processing enzyme that catalyzes the first step in cap formation. The 2.05 A crystal structure of yeast RNA triphosphatase Cet1p reveals a novel active site fold whereby an eight-stranded beta barrel forms a topologically closed triphosphate tunnel. Interactions of a sulfate in the center of the tunnel with a divalent cation and basic amino acids projecting into the tunnel suggest a catalytic mechanism that is supported by mutational data. Discrete… CONTINUE READING
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