Structure and Mechanism of Kainate Receptor Modulation by Anions

  title={Structure and Mechanism of Kainate Receptor Modulation by Anions},
  author={Andrew J. R. Plested and Mark L Mayer},
L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors by glutamate requires the presence of both Na(+) and Cl(-) in the… CONTINUE READING


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