Structure and Mechanism of DNA Polymerase β

  title={Structure and Mechanism of DNA Polymerase β},
  author={William A. Beard and Samuel H. Wilson},
DNA polymerase (pol) β is a small eukaryotic DNA polymerase composed of two domains. Each domain contributes an enzymatic activity (DNA synthesis and deoxyribose phosphate lyase) during the repair of simple base lesions. These domains are termed the polymerase and lyase domains, respectively. Pol β has been an excellent model enzyme for studying the nucleotidyl transferase reaction and substrate discrimination at a molecular level. In this review, recent crystallographic studies of pol β in… CONTINUE READING


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