Structure and Functions of Eukaryotic Nuclear DNA-Dependent RNA Polymerase I

  title={Structure and Functions of Eukaryotic Nuclear DNA-Dependent RNA Polymerase I},
  author={Elena K. Shematorova and George V. Shpakovski},
  journal={Molecular Biology},
In the eukaryotic cell, normal protein biosynthesis is sustained by several million ribosomes, which contain rRNA as an essential component. The high-molecular-weight precursor of large and 5.8S rRNAs is synthesized by DNA-dependent RNA polymerase I (Pol I) in the nucleolus. Data on DNA regulatory elements, protein factors involved in rDNA transcription by Pol I, subunit composition of Pol I, and on the interactions and possible functions of individual subunits are summarized. 


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