Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

@inproceedings{Trempe2013StructureAF,
  title={Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection},
  author={Jean-François Trempe and Edward A. Fon},
  booktitle={Front. Neurol.},
  year={2013}
}
Autosomal recessive forms of Parkinson's disease are caused by mutations in three genes: Parkin, PINK1, and DJ-1. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate substrates and to trigger proteasome-dependent degradation or autophagy, two crucial homeostatic processes in neurons. PINK1 is a mitochondrial protein kinase whose activity is required for Parkin… CONTINUE READING