Structure and Evolutionary Origin of Ca2+-Dependent Herring Type II Antifreeze Protein

@article{Liu2007StructureAE,
  title={Structure and Evolutionary Origin of Ca2+-Dependent Herring Type II Antifreeze Protein},
  author={Yang Liu and Zhengjun Li and Qingsong Lin and Jan Kosinski and Jayaraman Seetharaman and Janusz M. Bujnicki and Jayaraman Sivaraman and Choy-leong Hew},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={271 - 283}
}
In order to survive under extremely cold environments, many organisms produce antifreeze proteins (AFPs). AFPs inhibit the growth of ice crystals and protect organisms from freezing damage. Fish AFPs can be classified into five distinct types based on their structures. Here we report the structure of herring AFP (hAFP), a Ca(2+)-dependent fish type II AFP. It exhibits a fold similar to the C-type (Ca(2+)-dependent) lectins with unique ice-binding features. The 1.7 A crystal structure of hAFP… CONTINUE READING

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Ice-Binding Proteins and Their Function.

Annual review of biochemistry • 2016
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