Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer

@inproceedings{MartinFernandez2019StructureAD,
  title={Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer},
  author={Marisa L. Martin-Fernandez and David T. Clarke and Selene Roberts and Laura C. Zanetti-Domingues and Francesco Luigi Gervasio},
  booktitle={Cells},
  year={2019}
}
The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer activation was ascertained. However, many years of structure determination has shown that EGFR is not completely understood. One challenge is that the many structure fragments stored at the PDB only provide a partial view because full-length proteins are flexible entities and dynamics play a key role in their… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 204 REFERENCES

Anton 2: Raising the Bar for Performance and Programmability in a Special-Purpose Molecular Dynamics Supercomputer

  • SC14: International Conference for High Performance Computing, Networking, Storage and Analysis
  • 2014
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

EGFR: tale of the C-terminal tail.

  • Protein science : a publication of the Protein Society
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

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