Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.

@article{Pascolutti2016StructureAD,
  title={Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.},
  author={Roberta Pascolutti and Xianqiang Sun and Joseph Kao and Roy L Maute and Aaron M. Ring and Gregory R. Bowman and Andrew C Kruse},
  journal={Structure},
  year={2016},
  volume={24 10},
  pages={1719-1728}
}
The immune checkpoint receptor PD-1 and its ligand, PD-L1, have emerged as key regulators of anti-tumor immunity in humans. Recently, we reported an ultra-high-affinity PD-1 mutant, termed high-affinity consensus (HAC) PD-1, which shows superior therapeutic efficacy in mice compared with antibodies. However, the molecular details underlying the action of this agent remain incompletely understood, and a molecular view of PD-1/PD-L1 interactions in general is only beginning to emerge. Here, we… CONTINUE READING
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