Structure and DNA-binding properties of the Bacillus subtilis SpoIIIE DNA translocase revealed by single-molecule and electron microscopies

@inproceedings{Cattoni2014StructureAD,
  title={Structure and DNA-binding properties of the Bacillus subtilis SpoIIIE DNA translocase revealed by single-molecule and electron microscopies},
  author={Diego I Cattoni and Shreyasi Thakur and Cédric Godefroy and Antoine Le Gall and Jos{\'e}phine Lai-Kee-Him and Pierre-Emmanuel Milhiet and Patrick S Bron and Marcelo N{\"o}llmann},
  booktitle={Nucleic acids research},
  year={2014}
}
SpoIIIE/FtsK are a family of ring-shaped, membrane-anchored, ATP-fuelled motors required to segregate DNA across bacterial membranes. This process is directional and requires that SpoIIIE/FtsK recognize highly skewed octameric sequences (SRS/KOPS for SpoIIIE/FtsK) distributed along the chromosome. Two models have been proposed to explain the mechanism by which SpoIIIE/FtsK interact with DNA. The loading model proposes that SpoIIIE/FtsK oligomerize exclusively on SpoIIIE recognition sequence… CONTINUE READING

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