Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.

@article{Xu2014StructureAC,
  title={Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2.},
  author={Junjie Xu and Taulant Bacaj and Amy Zhou and Diana R Tomchick and Thomas C S{\"u}dhof and Josep Rizo},
  journal={Structure},
  year={2014},
  volume={22 2},
  pages={269-80}
}
Contacts between the endoplasmic reticulum and the plasma membrane involve extended synaptotagmins (E-Syts) in mammals or tricalbins in yeast, proteins with multiple C₂ domains. One of the tandem C₂ domains of E-Syt2 is predicted to bind Ca²⁺, but no Ca²⁺-dependent function has been attributed to this protein. We have determined the crystal structures of the tandem C₂ domains of E-Syt2 in the absence and presence of Ca²⁺ and analyzed their Ca²⁺-binding properties by nuclear magnetic resonance… CONTINUE READING
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PI ( 4 , 5 ) P 2 - dependent and Ca 2 + - regulated ERPM interactions mediated by the extended synaptotagmins

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