Structure and Assembly of the Yeast V-ATPase

@article{Graham2003StructureAA,
  title={Structure and Assembly of the Yeast V-ATPase},
  author={Laurie A. Graham and Andrew R. Flannery and Tom H. Stevens},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2003},
  volume={35},
  pages={301-312}
}
The yeast V-ATPase belongs to a family of V-type ATPases present in all eucaryotic organisms. In Saccharomyces cerevisiae the V-ATPase is localized to the membrane of the vacuole as well as the Golgi complex and endosomes. The V-ATPase brings about the acidification of these organelles by the transport of protons coupled to the hydrolysis of ATP. In yeast, the V-ATPase is composed of 13 subunits consisting of a catalytic V1 domain of peripherally associated proteins and a proton-translocating… 
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PKR1 Encodes an Assembly Factor for the Yeast V-Type ATPase*
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The data indicate that Pkr1p functions together with the other V-ATPase assembly factors in the ER to efficiently assemble the V- ATPase membrane sector.
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TLDR
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