Structure-activity studies reveal two allatostatin receptor types in corpora allata of Diploptera punctata.

@article{Feyereisen1997StructureactivitySR,
  title={Structure-activity studies reveal two allatostatin receptor types in corpora allata of Diploptera punctata.},
  author={Ren{\'e} Feyereisen and Norbert Siegel and Kam F Fok and G Chandran Unnithan and Geraldine Pratt},
  journal={Journal of insect physiology},
  year={1997},
  volume={43 7},
  pages={627-634}
}
Synthetic variants of the octadecapeptide amide ASB2 (AYSYVSEYKRLPVYNFGL-NH(2)), a cockroach allatostatin, were assayed in vitro on corpora allata (CA) from 2-day-old (vitellogenic) and 10-day-old (post-vitellogenic) female Diploptera punctata. The analogs [(17)psi(18),CH(2)-S]ASB2, [D-Trp(17)]ASB2 and [Ile(18)]ASB2 inhibited juvenile hormone (JH) synthesis with simple dose-response curves on sensitive CA from 10-day-old females. These analogs were fully effective but less potent than ASB2… CONTINUE READING